Police say Main Road in Kirk Michael will be closed for several hours following an accident outside the village shop.
According to witnesses, the accident involved a car and cyclist at around 6pm.
Motorists are advised to take an alternative route while investigations take place.
A statement from police said: ‘Efforts are being made for residents to be given access and egress and we would ask, unless a resident, that drivers avoid the area completely.
‘We would like to thank drivers in the area for their patience in this regard as officers have reported that all have been understanding in relation to the necessary diversions.’
Bus services have been disrupted.
A press release issued this evening said that services 5 and 6 departing Douglas will run as far as Douglas Road Corner, returning from Kirk Michael as per timetable. A shuttle service will run from Ramsey to Kirk Michael petrol station as per the timetable. This will be in place for the remainder of the evening.