Thieves struck in Ramsey during the early hours of Monday.
Now police are appealing for anyone who may have seen anyone acting suspiciously to get in touch.
The area affected led from Market Square, along the Quay through to Derby Road.
Anyone who had any items removed from vehicles or unlocked premises is being urged to contact police.
A selection of tools and carrying cases have been recovered and officers would like to reunite the items with their owners.
Residents are being urged to ensure their vehicles are secure and to not leave items on view, especially coming up to the Christmas period.
Contact Constable Kath Giles at Ramsey police station on 812234 or Crimestoppers anonymously on 0800 555 111.