The sides are two of four teams all locked together on 12 points after the opening few weeks of the season, with the Millers lying third - three places above Youthie - by virtue of a much superior goal difference.
Form would suggest a Mills win after four successive victories whereas Youthie have won two and lost two, but the northerners have already beaten the hotly-tipped Ayre United and will be fired up under new manager Andy Black.
Expect a close battle that could go either way, but home advantage may just see the Millers sneak it.
Unfortunately the eagerly-anticipated Friday night clash between the top two, St John’s and Braddan, has been postponed as a result of a waterlogged pitch at Mullen-e-Cloie.
An intriguing match could be on the cards at the Nivison Stadium where Onchan host Michael United on Saturday. Only two points separate the sides in the Os’ favour, but with Ciaran McNulty in fine scoring form, the westerners may get something from this clash.
Should any of the sides above them drop points, Ayre United will be ready to pounce as they start as sure-fire favourites against Governor’s Athletic, while Colby will be expected to get the better of Douglas and District at the Station Fields.
The final game on Saturday sees in-form Foxdale travel to winless Gymns.